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        Home >> Product Center >> Cardiovascular diseases >> Troponin I / creatine kinase isoenzyme MB / myoglobin combined test kit
        • Name: Troponin I / creatine kinase isoenzyme MB / myoglobin combined test kit


        [Description]: the product can be used with Bioda immune detector to quantitatively detect troponin I, creatine kinase isoenzyme MB and myoglobin in human whole blood, serum and plasma, and it can provide the reference for clinical diagnosis of myocardial infarction.

        [Detailed information]: cTnI-CKMB-Myo produced by our company is an in-vitro diagnostic reagent used to detect cTnI, CKMB and Myo protein in human whole blood, serum and plasma.

        In intact myocardial cell membrane, cTnI cannot enter the blood circulation through the cell membrane, so there is no or very low cTnI in the blood of healthy people. In patients with acute myocardial infarction, the cTnI released to the circulatory system will exceed the normal upper limit about 4-6h after the onset of symptom; in 12-24h after such onset, the cTnI concentration will reach the peak value, and then maintain a high level for 6-10 days. Since cTnI has high myocardial specificity and sensitivity, it is a relatively good definitive myocardial marker for early AMI diagnosis, prognosis evaluation and early unstable angina pectoris diagnosis.

        The creatine kinase contains three isoenzymes, and it is a dimer consisting of two types of monomers, while it exists in three different forms: CK-MM (muscular form), CK-MB (myocardial form), CK-BB (brain form). MB isoenzyme accounts for about 15-20% of the total CK, and only exists in cardiac muscle tissue, which makes itself have diagnostic value and become valuable marker for diagnosing myocardial damage. The existence of CK-MB in serum indicates that the myocardial damage is suspected. The monitoring of CK-MB is very important for the diagnosis of myocardial ischemia. For acute myocardial infarction and myocarditis, CK-MB will rise in 3-8h of chest pain.

        Myoglobin mainly exists in striated muscle (myocardium and skeletal muscle) cells and plays an important role in the membrane oxidation. As it is a kind of small molecular substance (relative molecular weight: 17,000-18,000), Mb is the first biomarker to enter the blood when myocardial cells are damaged, of which diffusion into the blood is faster than CK-MB mass or cTnI/cTnT. However, due to the expression of myoglobin in skeletal muscle, a large number of myoglobin can also be released in case of skeletal muscle injury, which is free from myocardial specificity. Myoglobin as a small molecular substance will flow into the blood rapidly in acute myocardial infarction (AMI). Therefore, the level of serum myoglobin can be dynamically detected twice for early diagnosis of AMI within 1.5-6 h after AMI. If the second detection value is significantly higher than the first one, the result is of very high positive prediction value; if there is no difference between the two dynamic detection values, the result is of good negative prediction value, excluding the possibility of AMI.


        [Reaction time]: 12min


        [Detection range] cTnI: 0.1-50ng/ml CKMB: 2-60ng / ml myo: 30-1000ng / ml


        [Clinical significance] diagnosis of myocardial damage and acute myocardial infarction (AMI), myocardial loss and myocarditis


        [Application departments] Outpatient Department, Emergency Department, Cardiology Department, Thoracic Surgery Department, Ambulance, Ward, ICU, Geriatrics Department


        [Interpretation method]:

        Detection results (ng/ml)

        Description

        Detection results (ng/ml)

        Description

        Detection results (ng/ml)

        Description

        cTnI0.25

        Negative

        CKMB4

        Negative

        Myo70

        Negative

        0.25≤cTnI0.5

        Myocardial damage

        CKMB≥4

        Myocardial damage

        Myo≥70

        Myocardial damage

        cTnI≥0.5

        Myocardial infarction (AMI)






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